Atypical Presentations of Progressive Disseminated Histoplasmosis in an Immunocompetent Adult: Ectopic Calcification (Aneurysm of Sinus of Valsalva) and Large Vessel (Left Subclavian Artery) Stenosis in the Background of Adrenal Insufficiency

Histoplasmosis is a systemic fungal disease caused by the dimorphic fungus Histoplasma capsulatum and more common in immunocompromised patients. can present with wide range of clinical manifestations from asymptomatic illness to severe organ dysfunctions may need hospitalization. major opportunistic infection North Central America. Disseminated histoplasmosis progressive extrapulmonary infection, hematogenous spread, mostly found immunosuppressed patients.
 Reports nonendemic regions are very rare. Due varied nonspecific histoplasmosis, most infections misdiagnosed or underreported.
 Here, we report case disseminated an immunocompetent individual non-endemic zone eastern India, presented long term fever along ectopic calcification (Aneurysm Sinus Valsalva) large vessel (left subclavian artery) stenosis background adrenal insufficiency.